产品货号：
Z38914
中文名称：
SHC/SHC1抗体
英文名称：
Anti-SHC/SHC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SHC/SHC1 Antibody |
| 指标别名 | SH2 domain protein C1;SHC;SHC transforming protein 1;SHC transforming protein 3;SHC transforming protein A;SHC1;SHCA |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | SHC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human SHC Signaling adapter that couples activated growth factor receptors to signaling pathways.Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.Isoform p46Shc and isoform p52Shc,once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. |
| 实际分子量 | 46/52/66KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SHC,also known as SHC1 (SHC-transforming protein 1) or SHCA,is a protein that in humans is encoded by the SHC1 gene.SCOP classifies the 3D structure as belonging to the SH2 domain family.This gene encodes three main isoforms that differ in activities and subcellular location.While all three are adapter proteins in signal transduction pathways,the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species.The other two isoforms,p52Shc and p46Shc,link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex.p66Shc is not involved in Ras activation.Unlike the other two isoforms,p46Shc is targeted to the mitochondrial matrix.Several transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P29353 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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